Gaffney is a town in and the seat of Cherokee County, South Carolina, United States, in the Upstate region of South Carolina. Gaffney is known as the "Peach Capital of South Carolina". The population was 12,539 at the 2010 census, with an estimated population of 12,597 in 2014. It is the principal city of the Gaffney, South Carolina, Micropolitan Statistical Area, which includes all of Cherokee County and which is further included in the greater Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area.